Benefits of coffee

I'm not going to give any commentary, except to say that dozens of more papers could be cited, including many cases of multiple replications of the same findings.


Ross GW. et al (2000). Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease. Journal of the American Medical Association, volume 283, issue 20, pages 2674-2679. Excerpt: "Our findings indicate that higher coffee and caffeine intake is associated with a significantly lower incidence of PD. This effect appears to be independent of smoking. The data suggest that the mechanism is related to caffeine intake and not to other nutrients contained in coffee."

Arendash GW, Cao C. (2010) Caffeine and coffee as therapeutics against Alzheimer's disease. Journal of Alzheimer's Disease, vol 20, pages 117-126. Excerpt: "Epidemiologic studies have increasingly suggested that caffeine/coffee could be an effective therapeutic against Alzheimer's disease [...] Caffeine appears to provide its disease-modifying effects through multiple mechanisms, including a direct reduction of Abeta production through suppression of both beta- and gamma-secretase levels. These results indicate a surprising ability of moderate caffeine intake (the human equivalent of 500 mg caffeine or 5 cups of coffee per day) to protect against or treat AD in a mouse model for the disease and a therapeutic potential for caffeine against AD in humans."

Brothers HM et al. (2010)  Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neuroscience Letters, volume 480, issue 2, pages 97-100. Excerpt: "Caffeine attenuated the number of activated microglia within the hippocampus of animals with LPS-induced and age-related inflammation."

Wang et al (2013).  Dietary polyphenols and colorectal cancer risk: The Fukuoka colorectal cancer study. World Journal of Gastroenterology, vol 19, issue 17, pages 2683–2690. Excerpt:  "The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption." Entire paper free here.

Espinosa J et al. (2013) Caffeine consumption prevents memory impairment,‭ ‬neuronal damage,‭ ‬and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia. Journal of Alzheimer's Disease (JAD), vol 34, issue, 2, pages 509-518. Excerpt: "Caffeine consumption (1 g/L in the drinking water starting 2 weeks before the STZ challenge) prevented the STZ-induced memory impairment and neurodegeneration". 

Lucas et al.  Coffee, caffeine, and risk of completed suicide: results from 3 prospective cohorts of American adults. The World Journal of Biological Psychiatry, volume 15, issue 5. Excerpt: "In these three large prospective cohorts of U.S. men and women, we observed that suicide risk, which was similar to that reported in age- and gender-specific U.S. mortality statistics (Rockett et al. 2010), decreased in a dose-dependent manner with increasing consumption of coffee. As compared with non-coffee drinkers, the pooled multivariate RR of suicide was 45% lower among individuals who consumed 2–3 cups of coffee per day, and 53% lower among individual consuming ≥4 cups of coffee per day. The lack of association between decaffeinated coffee and suicide risk suggests that caffeine, rather than other coffee components, contributes to this association." Entire paper free here.


Fujii et al (2015). Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice. Journal of Nutritional Science. Excerpt: "We conclude that dietary coffee polyphenols augment gut-derived active GLP-1 secretion via the cAMP-dependent pathway, which may contribute to the reduced risk of type 2 diabetes associated with daily coffee consumption."
Full paper available for free here.