For someone on FB

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Some of the confusion may be stemming from the word "how," which often carries mechanistic connotations...

So e.g. suppose that somebody asks me, "HOW can a person have debilitating hypersensitivity to multiple and unrelated chemicals without it being IgE-mediated?" I would reply by inviting them to read the work of Pall and others, whose work provides good evidence that excessive production of endogenous nitric oxide (NO) is involved in some cases. NO can keep itself elevated through several positive feedback loops (e.g. NO reacts with superoxide to make peroxynitrite which in turn can increase production of both its precursors!) and that NO can theoretically cause such extreme hypersensitivity given (a) its ability to simultaneously enhance NMDA activity while depleting ATP (it's known that cells containing NMDA receptors become hypersensitive to stimuli when deprived of ATP), (B) the ability of peroxynitrite to cause blood brain barrier permeability, (c) NO's ability to inhibit p450s, (d) etc (more mechanisms have been outlined, including insights on vallinoid receptors). I would also note that animal and human studies (including replicated genetic studies) show some involvement of NO in many alleged MCS cases.

Ok, long winded, but that's one kind of a "how" question. It involves detailing physical *mechanisms.*  So it might be confusing to ask "how" there could be nonphysical reality. Perhaps it would be clearer to ask something like the following:

*Why* should we conclude that any aspect of reality is nonphysical or that reality is ultimately grounded in a nonphysical Source? Are there any good reasons for thinking so?

On this latter question I would repeat my recommendation that you read and engage arguments for classical theism. If you make a case for (some version of) PSR and then combine it the classical arguments from "motion" (by which one usually means actualization of potential a la Feser, Kerr, or Hart) or from composites (eg Feser or Fradd), etc. *then,* as noted earlier, you will be taken back to a necessary Source of reality that is nonphysical. 

Or are you asking about nonphysical realities other than the God of classical theism? Are you asking about "souls?" Afterlife? Abstract objects? 

If PSR is true, and if all physical reality is contingent, then it's plausible that physical reality is grounded in and/or emanates from a logically-prior Source that isn't physical, and this would be the case even if the past is infinite. This still requires a lot of unpacking, and I certainly don't expect you to be persuaded by anything written so far, but is this at least helpful in moving the conversation forward?